SMOX antibody (AA 45-454)

Catalog No. ABIN7875072

The Rabbit Polyclonal anti-SMOX antibody is suitable to detect SMOX in samples from Human, Mouse and Rat. It has been validated for ELISA, WB, IF, FACS and IHC (p).

Quick Overview for SMOX antibody (AA 45-454) (ABIN7875072)

Target: SMOX (Spermine Oxidase (SMOX))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMOX antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SMOX Antibody

Binding Specificity: AA 45-454

Purpose: PAO-1 Antibody / Polyamine oxidase 1 / SMOX

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E45-Q454) was used as the immunogen for the PAO-1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PAO-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PAO-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SMOX

Target: SMOX (Spermine Oxidase (SMOX))

Alternative Name: PAO-1

Background: Spermine oxidase, also called Polyamine oxidase 1 (PAO-1), is an enzyme that in humans is encoded by the SMOX gene. Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.

UniProt: Q9NWM0