Recombinant AMH antibody (AA 460-560)

Catalog No. ABIN7875130

The Rabbit Monoclonal anti-AMH antibody (Clone AMH-6713R) (ABIN7875130) specifically detects AMH in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant AMH antibody (AA 460-560) (ABIN7875130)

Target: AMH (Anti-Mullerian Hormone (AMH))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This AMH antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AMH-6713R

Product Details anti-AMH Antibody

Binding Specificity: AA 460-560

Purpose: Muellerian Inhibiting Factor Antibody / Anti-Muellerian Hormone

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 460-560 from the human protein was used as the immunogen for the Muellerian Inhibiting Factor antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Muellerian Inhibiting Factor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Muellerian Inhibiting Factor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Alternative Name: Muellerian Inhibiting Factor

Background: The transforming growth factor superfamily proteins are involved in embryonic development and adult tissue homeostasis. The Muellerian inhibiting factor (MIF), also called Muellerian-inhibiting substance (MIS) and Anti-Muellerian hormone (AMH), glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIF and testosterone, the presence of which result in male offspring. Absence of MIF and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIF causes regression of the Muellerian duct. MIF inhibits the growth of tumors derived from tissues of Mullerian duct origin. It can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion