TAB1 antibody (AA 5-329)

Catalog No. ABIN7875305

This Rabbit Polyclonal antibody specifically detects TAB1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for TAB1 antibody (AA 5-329) (ABIN7875305)

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TAB1 Antibody

Binding Specificity: AA 5-329

Purpose: TAB1 Antibody / TAK1-binding protein 1 / MAP3K7IP1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids R5-A329) was used as the immunogen for the TAB1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TAB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TAB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TAB1

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Alternative Name: TAB1

Background: Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, also called TAB1, is an enzyme that in humans is encoded by the MAP3K7IP1 gene. It is mapped to 22q13.1. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways. This protein can interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. TAB1 also can activate the kinase activity of TAK1 by direct interaction, and it may be an important signaling intermediate between TGFB receptors and TAK1. What's more, TAB1 plays an important role in skin homeostasis, wound repair, and oncogenesis.

UniProt: Q15750

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades