AMPD1 antibody (AA 5-747)

Catalog No. ABIN7875316

The Rabbit Polyclonal anti-AMPD1 antibody (ABIN7875316) specifically detects AMPD1 in ELISA, WB, IHC and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for AMPD1 antibody (AA 5-747) (ABIN7875316)

Target: AMPD1 (Adenosine Monophosphate Deaminase 1 (AMPD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMPD1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-AMPD1 Antibody

Binding Specificity: AA 5-747

Purpose: AMPD1 Antibody / AMP deaminase 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human AMPD1 recombinant protein (Position: K5-E747) was used as the immunogen for the AMPD1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the AMPD1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the AMPD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for AMPD1

Target: AMPD1 (Adenosine Monophosphate Deaminase 1 (AMPD1))

Alternative Name: AMPD1

Background: AMPD1 antibody detects Adenosine monophosphate deaminase 1, encoded by the AMPD1 gene. Adenosine monophosphate deaminase 1 is a skeletal muscle-specific enzyme of the purine nucleotide cycle, responsible for converting AMP to IMP. AMPD1 antibody provides researchers with a useful reagent for studying muscle metabolism, energy homeostasis, and exercise physiology.

Adenosine monophosphate deaminase 1 is highly expressed in skeletal muscle and plays a key role in energy regulation during periods of high metabolic demand. Research using AMPD1 antibody has shown that the enzyme supports ATP regeneration by facilitating nucleotide turnover. Its activity ensures maintenance of energy balance in contracting muscle fibers and contributes to endurance capacity.

Studies with AMPD1 antibody have revealed that genetic deficiency of AMPD1 is one of the most common enzymatic defects in human muscle. Mutations in AMPD1 result in myoadenylate deaminase deficiency, a condition characterized by exercise intolerance, fatigue, and muscle pain. These findings demonstrate the clinical significance of AMPD1 in skeletal muscle health.

Beyond muscle, Adenosine monophosphate deaminase 1 may play roles in purine metabolism affecting systemic energy balance. Research using AMPD1 antibody has shown that altered expression influences nucleotide pools and cellular signaling, with possible implications in metabolic disease and cardiovascular function. AMPD1 is also studied for its potential contribution to purine-related disorders and immune responses.

AMPD1 antibody is widely applied in enzyme assays, western blotting, and immunohistochemistry. Enzyme assays confirm catalytic activity in skeletal muscle biopsies, western blotting quantifies expression in normal and deficient tissues, and immunohistochemistry highlights distribution within muscle fibers. These applications make AMPD1 antibody essential in both basic and clinical research.

By supplying validated AMPD1 antibody reagents, NSJ Bioreagents supports studies into purine metabolism, muscle physiology, and metabolic disorders. Detection of Adenosine monophosphate deaminase 1 provides researchers with insight into how purine cycle enzymes regulate energy balance in skeletal muscle.

UniProt: P23109