CEACAM1 antibody (AA 50-250)

Catalog No. ABIN7875347

This Mouse Monoclonal antibody specifically detects CEACAM1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for CEACAM1 antibody (AA 50-250) (ABIN7875347)

Target: CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CEACAM1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CEACAM1-4840

Product Details anti-CEACAM1 Antibody

Binding Specificity: AA 50-250

Purpose: CEACAM1 Antibody / Biliary glycoprotein 1 / BGP-1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the CEACAM1 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the CEACAM1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CEACAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CEACAM1

Target: CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))

Alternative Name: CEACAM1

Background: Carcinoembryonic antigen (CEA) is one of the most commonly used tumor markers in serum immunoassay determinations of carcinoma. Members of the CEACAM (carcinoembryonic antigen-related cell adhesion molecule) family contain a single N domain, with structural homology to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. CEACAM1, also called Biliary glycoprotein 1 (BGP-1), is a 526 amino acid protein that exists as seven alternatively spliced isoforms, some of which localize to the cell membranes, while others are secreted. One of several members of the CEACAM family, CEACAM1 contains one Ig-like V-type domain and three Ig-like C2-type domains and is thought to play a role in a variety of cellular activities, including angiogenesis, apoptosis, arrangement of tissue three dimensional structure and modulation of innate and adaptive immune responses. Additionally, CEACAM1 is under-expressed in colorectal cancers, suggesting a role in tumor suppression.

UniProt: P13688