Recombinant GLUL antibody (AA 50-250)

Catalog No. ABIN7875375

The Rabbit Monoclonal anti-GLUL antibody is suitable to detect GLUL in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant GLUL antibody (AA 50-250) (ABIN7875375)

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GLUL antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: GLUL-8517R

Product Details anti-GLUL Antibody

Binding Specificity: AA 50-250

Purpose: GLUL Antibody / Glutamine Synthetase (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the GLUL antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the GLUL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the GLUL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GLUL

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Alternative Name: GLUL

Background: Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

UniProt: P15104

Pathways: Positive Regulation of Peptide Hormone Secretion