Recombinant GLUL antibody (AA 50-250)

Catalog No. ABIN7875376

The Rabbit Monoclonal anti-GLUL antibody (Clone GLUL-8517R) (ABIN7875376) specifically detects GLUL in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant GLUL antibody (AA 50-250) (ABIN7875376)

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GLUL antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GLUL-8517R

Product Details anti-GLUL Antibody

Binding Specificity: AA 50-250

Purpose: GLUL Antibody / Glutamine Synthetase

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the GLUL antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the GLUL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GLUL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GLUL

Target: GLUL (Glutamate-Ammonia Ligase (GLUL))

Alternative Name: GLUL

Background: Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

UniProt: P15104

Pathways: Positive Regulation of Peptide Hormone Secretion