TGFB3 antibody (AA 50-250)

Catalog No. ABIN7875398

This Mouse Monoclonal antibody specifically detects TGFB3 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for TGFB3 antibody (AA 50-250) (ABIN7875398)

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGFB3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TGFB3-4801

Product Details anti-TGFB3 Antibody

Binding Specificity: AA 50-250

Purpose: TGF beta 3 Antibody / TGFB3

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the TGF beta 3 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the TGF beta 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TGF beta 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TGFB3

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Alternative Name: TGF beta 3

Background: Transforming growth factor betas (TGF-betas) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF-beta. TGF-beta 1, TGF-beta 2 and TGF-beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. TGF-beta 3 mediates many intercellular interactions that occur during embryonic development, cell differentiation and epithelial homeostasis. TGF-beta 3 overexpresses in extramammary Paget s disease (EPD) and downregulates in Bowen s disease, indicating that its expression is a useful indicator of tumor activity. TGF-beta 3 levels strongly correlate with IGF-1 and osteocalcin levels in serum. Significant amounts of TGF-beta 3 circulation appear to be representative of TGFbeta 3 expression in bone and may in part be derived from bone. Glucocorticoids may block TGF-beta production by modulating mRNA levels and c-Jun activity.

UniProt: P10600

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus