ECD/SGT1 antibody (AA 50-567)

Catalog No. ABIN7875412

The Rabbit Polyclonal anti-ECD/SGT1 antibody (ABIN7875412) specifically detects ECD/SGT1 in WB, ELISA, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for ECD/SGT1 antibody (AA 50-567) (ABIN7875412)

Target: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ECD/SGT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-ECD/SGT1 Antibody

Binding Specificity: AA 50-567

Purpose: ECD Antibody / SGT1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids L50-Q567) was used as the immunogen for the ECD antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ECD antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ECD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ECD/SGT1

Target: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Alternative Name: ECD

Background: Protein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

UniProt: O95905

Pathways: Regulation of Carbohydrate Metabolic Process