DNMT1 antibody (AA 509-1577)

Catalog No. ABIN7875507

The Rabbit Polyclonal anti-DNMT1 antibody is suitable to detect DNMT1 in samples from Mouse. It has been validated for WB and ELISA.

Quick Overview for DNMT1 antibody (AA 509-1577) (ABIN7875507)

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNMT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DNMT1 Antibody

Binding Specificity: AA 509-1577

Purpose: DNA methyltransferase 1 Antibody / Dnmt1

Purification: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids Q509-Q1577) was used as the immunogen for the DNA methyltransferase 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DNA methyltransferase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the DNA methyltransferase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for DNMT1

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Alternative Name: DNA methyltransferase 1

Background: DNA (cytosine-5)-methyltransferase 1 is an enzyme that in humans is encoded by the DNMT1 gene. This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

UniProt: P13864

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection