PLA2G1B antibody (AA 513-541)

Catalog No. ABIN7875533

This Rabbit Polyclonal antibody specifically detects PLA2G1B in WB, IF, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for PLA2G1B antibody (AA 513-541) (ABIN7875533)

Target: PLA2G1B (Phospholipase A2, Group IB (PLA2G1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA2G1B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PLA2G1B Antibody

Binding Specificity: AA 513-541

Purpose: Phospholipase A2 Antibody / PLA2G4A / cPLA2

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 513-541 from the human protein was used as the immunogen for the Phospholipase A2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Phospholipase A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Phospholipase A2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PLA2G1B

Target: PLA2G1B (Phospholipase A2, Group IB (PLA2G1B))

Alternative Name: Phospholipase A2

Background: PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

UniProt: P47712

Pathways: Inositol Metabolic Process, VEGF Signaling