GIMAP4 antibody (AA 53-224)

Catalog No. ABIN7875592

The Rabbit Polyclonal anti-GIMAP4 antibody (ABIN7875592) specifically detects GIMAP4 in WB, ELISA, IHC and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GIMAP4 antibody (AA 53-224) (ABIN7875592)

Target: GIMAP4 (GTPase, IMAP Family Member 4 (GIMAP4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIMAP4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-GIMAP4 Antibody

Binding Specificity: AA 53-224

Purpose: GIMAP4 Antibody / GTPase IMAP family member 4

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human GIMAP4 recombinant protein (Position: R53-R224) was used as the immunogen for the GIMAP4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GIMAP4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GIMAP4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GIMAP4

Target: GIMAP4 (GTPase, IMAP Family Member 4 (GIMAP4))

Alternative Name: GIMAP4

Background: GIMAP4 antibody detects GTPase IMAP family member 4, encoded by the GIMAP4 gene. GTPase IMAP family member 4 is a small GTP binding protein expressed in lymphoid tissues, where it regulates apoptosis and immune homeostasis. GIMAP4 antibody provides researchers with a tool for studying lymphocyte biology, programmed cell death, and immune regulation.

GTPase IMAP family member 4 is a member of the GIMAP (GTPase of the immunity-associated protein) family, which is enriched in hematopoietic cells. Research using GIMAP4 antibody has shown that it localizes to the cytoplasm and regulates T cell apoptosis by influencing mitochondrial membrane potential and caspase activation. These findings highlight its role in immune cell turnover and tolerance.

Studies with GIMAP4 antibody have demonstrated that loss of GIMAP4 function alters T cell lifespan, disrupting normal immune balance. In model organisms, deficiency of GIMAP4 results in prolonged T cell survival and immune dysregulation. Conversely, overexpression enhances apoptosis, suggesting that GIMAP4 fine-tunes immune cell homeostasis.

Dysregulation of GTPase IMAP family member 4 has been associated with autoimmune disease and cancer. Research using GIMAP4 antibody has shown that altered expression influences susceptibility to autoimmune conditions, where prolonged T cell survival contributes to autoreactivity. Reduced expression has been observed in certain leukemias, suggesting tumor suppressive functions.

GIMAP4 antibody is widely applied in immunohistochemistry, western blotting, and flow cytometry. Immunohistochemistry highlights expression in lymphoid tissues, western blotting quantifies levels in T cell lines, and flow cytometry identifies expression across immune cell subsets. These applications make GIMAP4 antibody indispensable in immunology research.

By providing validated GIMAP4 antibody reagents, NSJ Bioreagents supports studies into apoptosis, immune regulation, and disease. Detection of GTPase IMAP family member 4 provides researchers with insight into how GTPases regulate lymphocyte homeostasis and pathology.

UniProt: Q9NUV9