LEMD3 antibody (AA 535-852)

Catalog No. ABIN7875610

The Rabbit Polyclonal anti-LEMD3 antibody (ABIN7875610) specifically detects LEMD3 in WB, FACS and ELISA. The antibody is reactive with Human samples.

Quick Overview for LEMD3 antibody (AA 535-852) (ABIN7875610)

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEMD3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Product Details anti-LEMD3 Antibody

Binding Specificity: AA 535-852

Purpose: MAN1 Antibody / LEMD3

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids H535-H852) was used as the immunogen for the MAN1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MAN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MAN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LEMD3

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Alternative Name: MAN1

Background: LEM domain-containing protein 3 (LEMD3), also known as MAN1, is an integral protein in the inner nuclear membrane (INM) of the nuclear envelope. It is encoded by the LEMD3 gene and was first identified after it was isolated from the serum of a patient with a collagen vascular disease. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

UniProt: Q9Y2U8