Occludin antibody (AA 54-270)

Catalog No. ABIN7875650

This Rabbit Polyclonal antibody specifically detects Occludin in WB, ELISA, FACS, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Occludin antibody (AA 54-270) (ABIN7875650)

Target: Occludin (OCLN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Occludin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Occludin Antibody

Binding Specificity: AA 54-270

Purpose: OCLN Antibody / Occludin

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids H54-K270) was used as the immunogen for the OCLN antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the OCLN antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the OCLN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Occludin

Target: Occludin (OCLN)

Alternative Name: OCLN

Background: Occludin is an integral membrane protein that is located at tight junctions. It is a member of a family of proteins containing the highly conserved Marvel domain, which contains 4 transmembrane-helix regions. This gene is mapped to 5q13.2. Occludin regulates TGF-beta receptor type I localization for efficient TGF-beta-dependent dissolution of tight junctions during epithelial-mesenchymal transitions. Human Occludin is an essential hepatitis C virus (HCV) cell entry factor that is able to render murine cells infectable with HCV glycoproteins. It has been found that occludin is involved in cell migration and functions to recruit active PI3 kinase to the leading edge, resulting in RAC1 activation and formation of lamellipodia.

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C