GLUD1 / GLUD2 (AA 54-553) antibody

Catalog No. ABIN7875655

The Rabbit Polyclonal anti-GLUD1 / GLUD2 antibody (ABIN7875655) specifically detects GLUD1 / GLUD2 in ELISA, WB, IF, FACS and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GLUD1 / GLUD2 (AA 54-553) antibody (ABIN7875655)

Target: GLUD1 / GLUD2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 54-553

Purpose: GLUD1/2 Antibody / GDH1/2

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids S54-A553) was used as the immunogen for the GLUD1/2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GLUD1/2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GLUD1/2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: GLUD1 / GLUD2

Alternative Name: GLUD1/2

Background: This gene encodes Glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.

UniProt: P00367