FKBP1A antibody (AA 55-83)

Catalog No. ABIN7875697

The Rabbit Polyclonal anti-FKBP1A antibody (ABIN7875697) specifically detects FKBP1A in WB, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for FKBP1A antibody (AA 55-83) (ABIN7875697)

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP1A antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FKBP1A Antibody

Binding Specificity: AA 55-83

Purpose: FKBP1A Antibody / FKBP12

Purification: Purified

Immunogen: A portion of amino acids 55-83 from the human protein was used as the immunogen for the FKBP1A antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the FKBP1A antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the FKBP1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FKBP1A

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Alternative Name: FKBP1A

Background: FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

UniProt: P62942

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process