ACTN2 antibody (AA 557-692)

Catalog No. ABIN7875735

The Mouse Monoclonal anti-ACTN2 antibody is suitable to detect ACTN2 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for ACTN2 antibody (AA 557-692) (ABIN7875735)

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACTN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ACTN2-3294

Product Details anti-ACTN2 Antibody

Binding Specificity: AA 557-692

Purpose: Actinin Alpha 2 Antibody / Sarcomeric Alpha Actinin / ACTN2

Purification: Protein G affinity chromatography

Immunogen: Amino acids 557-692 from the human protein were used as the immunogen for this ACTN2 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Actinin Alpha 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Actinin Alpha 2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ACTN2

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Alternative Name: Actinin Alpha 2

Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: P35609

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity