EPH Receptor A3 antibody (AA 59-514)

Catalog No. ABIN7875906

The Rabbit Polyclonal anti-EPH Receptor A3 antibody is suitable to detect EPH Receptor A3 in samples from Human. It has been validated for WB, ELISA, IHC (p), IF and FACS.

Quick Overview for EPH Receptor A3 antibody (AA 59-514) (ABIN7875906)

Target: EPH Receptor A3 (EPHA3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-EPH Receptor A3 Antibody

Binding Specificity: AA 59-514

Purpose: Eph receptor A3 Antibody / EphA3

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D59-A514) was used as the immunogen for the Eph receptor A3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Eph receptor A3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Eph receptor A3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for EPH Receptor A3

Target: EPH Receptor A3 (EPHA3)

Alternative Name: Eph receptor A3

Background: Ephrin Receptor EphA3, is also known as human embryo kinase(HEK) or Eph-like tyrosine kinase1(ETK1). Kinases that phosphorylate proteins on tyrosine residues(protein tyrosine kinases, PTKs), such as EPHA3, form a structurally related group of molecules that exhibit functional diversity. Genetic alterations that lead to the inappropriate activation or expression of PTKs may be oncogenic. Many growth factor receptors are PTKs, e.g., the receptors for epidermal growth factor(EGFR), platelet-derived growth factor(PDGFR1,PDGFR2), colony-stimulating factor-1(CSF1R), and stem cell growth factor. The EPHA3 gene is mapped to 3p11.2. Sequence comparison with other PTKs showed a high degree of homology with members of the EPH and ELK(EPHB1) families of receptor tyrosine kinases. Within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections.

UniProt: P29320

Pathways: RTK Signaling, Regulation of Cell Size