NUMB antibody (AA 59-567)

Catalog No. ABIN7875909

The Rabbit Polyclonal anti-NUMB antibody is suitable to detect NUMB in samples from Human, Mouse, Rat and Monkey. It has been validated for WB, ELISA and FACS.

Quick Overview for NUMB antibody (AA 59-567) (ABIN7875909)

Target: NUMB (Numb Homolog (NUMB))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-NUMB Antibody

Binding Specificity: AA 59-567

Purpose: NUMB Antibody

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids E59-A567) was used as the immunogen for the NUMB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NUMB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NUMB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NUMB

Target: NUMB (Numb Homolog (NUMB))

Alternative Name: NUMB

Background: Protein numb homolog is a protein that in humans is encoded by the NUMB gene. It is mapped to 14q24.2 to q24.3. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Whati 1/2s more, the numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

UniProt: P49757

Pathways: Cell-Cell Junction Organization