APOB antibody (AA 592-689)

Catalog No. ABIN7875926

This Mouse Monoclonal antibody specifically detects APOB in IHC (p). It exhibits reactivity toward Human.

Quick Overview for APOB antibody (AA 592-689) (ABIN7875926)

Target: APOB (Apolipoprotein B (APOB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: APOB-3300

Product Details anti-APOB Antibody

Binding Specificity: AA 592-689

Purpose: APOB Antibody / Apolipoprotein B

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 592-689 from the human protein was used as the immunogen for the APOB antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the APOB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the APOB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for APOB

Target: APOB (Apolipoprotein B (APOB))

Alternative Name: APOB

Background: Post-transcriptional editing of apolipoprotein B (apoB) mRNA is regulated by APOBEC1 (also designated human (or rat) small intestinal apolipoprotein B mRNA editing protein, HEPR or REPR) in hepatic cells to achieve a steady state proportion of edited and unedited RNA molecules. Two forms of apoB are known to circulate in the plasma of mammals. ApoB-100 is a protein primarily synthesized in the liver as a structural component of very low density lipoprotein particles. A truncated form of apoB-100, apoB-48, is synthesized in the small intestine and contains the amino-terminal 2,152 amino acids of the larger protein. This organ-specific partitioning of apoB production is the resultof RNA editing of a common apoB gene.

UniProt: P04114

Pathways: Lipid Metabolism