GPC1 antibody (AA 6-31)

Catalog No. ABIN7875951

The Rabbit Polyclonal anti-GPC1 antibody is suitable to detect GPC1 in samples from Human. It has been validated for WB, FACS and IHC (p).

Quick Overview for GPC1 antibody (AA 6-31) (ABIN7875951)

Target: GPC1 (Glypican 1 (GPC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPC1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GPC1 Antibody

Binding Specificity: AA 6-31

Purpose: Glypican-1 Antibody / GPC1

Immunogen: A portion of amino acids 6-31 from the human protein was used as the immunogen for the Glypican-1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Glypican-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Glypican-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GPC1

Target: GPC1 (Glypican 1 (GPC1))

Alternative Name: Glypican-1

Background: Glypican-1, also known as GPC1, is a glycosylphosphatidylinositol (GPI)-anchored cell surface proteoglycan that plays a crucial role in various cellular processes, including cell growth, differentiation, and signaling pathways. Recent studies have shown that GPC1 is overexpressed in many types of cancer, including pancreatic, breast, and prostate cancer. This overexpression is thought to contribute to the aggressiveness and metastatic potential of these tumors, making GPC1 a potential target for cancer therapy. One of the key functions of GPC1 in cancer is its ability to interact with growth factors and signaling molecules, such as Wnt and Hedgehog, to promote tumor growth and progression. By blocking the interaction between GPC1 and these molecules, researchers believe they can inhibit the growth of cancer cells and potentially prevent metastasis. In addition to its role in promoting cancer progression, GPC1 has also been found to be a promising biomarker for early detection and prognosis of cancer. Researchers have developed novel diagnostic tools that detect circulating GPC1 levels in the blood, allowing for earlier detection of cancer and more accurate monitoring of treatment response.

UniProt: P35052

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation