COPS5 antibody (AA 6-332)

Catalog No. ABIN7875952

The Rabbit Polyclonal anti-COPS5 antibody (ABIN7875952) specifically detects COPS5 in WB and IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for COPS5 antibody (AA 6-332) (ABIN7875952)

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-COPS5 Antibody

Binding Specificity: AA 6-332

Purpose: Zebrafish Jab1 Antibody / Jun activation domain-binding protein 1 / Cops5

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Jab1/COPS5 recombinant protein (amino acids I6-S332) was used as the immunogen for the Zebrafish Jab1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Jab1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Jab1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Alternative Name: Jab1

Background: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.

UniProt: Q6PC30

Pathways: Cell Division Cycle