FBXO32 antibody (AA 6-355)

Catalog No. ABIN7875957

The Rabbit Polyclonal anti-FBXO32 antibody is suitable to detect FBXO32 in samples from Human and Mouse. It has been validated for WB, ELISA, IF and FACS.

Quick Overview for FBXO32 antibody (AA 6-355) (ABIN7875957)

Target: FBXO32 (F-Box Protein 32 (FBXO32))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO32 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-FBXO32 Antibody

Binding Specificity: AA 6-355

Purpose: FBXO32 Antibody / F-box only protein 32 / Atrogin 1

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids Q6-F355) was used as the immunogen for the FBXO32 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FBXO32 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the FBXO32 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for FBXO32

Target: FBXO32 (F-Box Protein 32 (FBXO32))

Alternative Name: FBXO32

Background: F-box only protein 32, also known as MAFbx, for Muscle Atrophy F-box gene, and Atrogin-1, is a protein that in humans is encoded by the FBXO32 gene. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q969P5