Pleiotrophin antibody (AA 61-148)

Catalog No. ABIN7876106

This Rabbit Polyclonal antibody specifically detects Pleiotrophin in WB, ELISA, IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Pleiotrophin antibody (AA 61-148) (ABIN7876106)

Target: Pleiotrophin (PTN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Pleiotrophin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-Pleiotrophin Antibody

Binding Specificity: AA 61-148

Purpose: HBBM Antibody / Heparin-binding brain mitogen / Pleiotrophin

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids D61-K148) was used as the immunogen for the HBBM antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PTN antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the HBBM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Pleiotrophin

Target: Pleiotrophin (PTN)

Alternative Name: HBBM

Background: Pleiotrophin (PTN), also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor 8 (HBGF-8), neurite growth-promoting factor 1 (NEGF1), heparin affinity regulatory peptide (HARP), heparin binding growth associated molecule (HB-GAM) and Osteoblast-specific factor 1 (OSF-1), is a protein that in humans is encoded by the PTN gene. PTN is the first member of a family of developmentally regulated cytokines. The PTN gene is mapped to 7q33-q34. A mutant PTN that contained only the first N-terminal 40 amino acids was a dominant negative. Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin binds to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.

UniProt: P21246

Pathways: RTK Signaling