PFKL antibody (AA 669-699)

Catalog No. ABIN7876365

The Rabbit Polyclonal anti-PFKL antibody is suitable to detect PFKL in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for PFKL antibody (AA 669-699) (ABIN7876365)

Target: PFKL (Phosphofructokinase, Liver (PFKL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PFKL Antibody

Binding Specificity: AA 669-699

Purpose: PFKL Antibody / ATP-PFK / ATP-dependent 6-phosphofructokinase liver type

Immunogen: A portion of amino acids 669-699 from the human protein was used as the immunogen for the PFKL antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the PFKL antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PFKL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PFKL

Target: PFKL (Phosphofructokinase, Liver (PFKL))

Alternative Name: PFKL

Background: The PFKL protein is an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, a key step in the glycolytic pathway. It also plays a role in regulating glucose metabolism, which is crucial for maintaining healthy blood sugar levels. Dysregulation of the PFKL protein has been linked to metabolic disorders such as diabetes and obesity. While it is primarily found in the liver, where it helps regulate glucose production, it is also found in other tissues such as skeletal muscle and adipose tissue.

UniProt: P17858

Pathways: Negative Regulation of Hormone Secretion, Warburg Effect