Oncostatin M Receptor antibody (AA 673-968)

Catalog No. ABIN7876393

The Rabbit Polyclonal anti-Oncostatin M Receptor antibody (ABIN7876393) specifically detects Oncostatin M Receptor in WB, ELISA and FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for Oncostatin M Receptor antibody (AA 673-968) (ABIN7876393)

Target: Oncostatin M Receptor (OSMR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oncostatin M Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Oncostatin M Receptor Antibody

Binding Specificity: AA 673-968

Purpose: Osmr Antibody / Oncostatin M receptor

Purification: Immunogen affinity purified

Immunogen: E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968) was used as the immunogen for the Osmr antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Osmr antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Osmr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Oncostatin M Receptor

Target: Oncostatin M Receptor (OSMR)

Alternative Name: Osmr

Background: OSMR antibody detects Oncostatin M receptor, a cytokine receptor that forms part of the type I cytokine receptor family and mediates signaling by the cytokines oncostatin M and interleukin-31. OSMR dimerizes with either gp130 or IL31RA to initiate downstream JAK-STAT, MAPK, and PI3K signaling cascades. The OSMR antibody is widely used in immunology, inflammation, and cancer research to study cytokine signaling, tissue remodeling, and immune regulation.

OSMR is encoded by the OSMR gene on human chromosome 5p13.1. The protein is approximately 100 kilodaltons and contains an extracellular cytokine-binding domain, a single transmembrane helix, and a cytoplasmic tail harboring signaling motifs that recruit JAK kinases and STAT transcription factors. OSMR is expressed in a wide range of cell types, including epithelial cells, fibroblasts, and immune cells, where it mediates diverse biological responses to inflammatory cues.

An OSMR antibody detects a 100-200 kilodalton band by western blot and exhibits membrane and perinuclear staining under immunofluorescence. Ligand binding induces heterodimerization of OSMR with gp130 or IL31RA, leading to phosphorylation of JAK1 and JAK2 and subsequent activation of STAT3 and STAT5 transcription factors. These pathways regulate genes involved in cell proliferation, differentiation, and extracellular matrix remodeling.

In the immune system, OSMR signaling modulates macrophage activation, Th2 cytokine production, and inflammation resolution. In epithelial tissues, OSMR promotes wound healing and regeneration but, when overactivated, contributes to chronic inflammation and fibrosis. Dysregulation of OSMR expression has been linked to psoriasis, asthma, and several cancers, where it enhances tumor progression through paracrine cytokine signaling.

Because of its dual role in inflammation and tissue regeneration, OSMR represents an important biomarker and therapeutic target in immune-mediated and neoplastic diseases. NSJ Bioreagents provides a validated OSMR antibody optimized for its applications, supporting research into cytokine receptor signaling, inflammatory pathways, and cancer biology.

UniProt: O70458

Pathways: JAK-STAT Signaling, Growth Factor Binding