LTB antibody (AA 68-306)

Catalog No. ABIN7876397

This Rabbit Polyclonal antibody specifically detects LTB in WB, ELISA and FACS. It exhibits reactivity toward Mouse and Rat.

Quick Overview for LTB antibody (AA 68-306) (ABIN7876397)

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LTB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-LTB Antibody

Binding Specificity: AA 68-306

Purpose: Lymphotoxin beta Antibody / Ltb

Purification: Antigen affinity purified

Immunogen: An E.coli-derived mouse recombinant protein (amino acids R68-G306) was used as the immunogen for the Lymphotoxin beta antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Lymphotoxin beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Lymphotoxin beta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LTB

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Alternative Name: Lymphotoxin beta

Background: Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 Molecule alpha/2 Molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: P41155

Pathways: NF-kappaB Signaling