Ribonuclease H1 antibody (AA 7-223)

Catalog No. ABIN7876470

The Rabbit Polyclonal anti-Ribonuclease H1 antibody is suitable to detect Ribonuclease H1 in samples from Human and Mouse. It has been validated for WB, ELISA, IF and FACS.

Quick Overview for Ribonuclease H1 antibody (AA 7-223) (ABIN7876470)

Target: Ribonuclease H1 (RNASEH1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ribonuclease H1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Ribonuclease H1 Antibody

Binding Specificity: AA 7-223

Purpose: Ribonuclease H1 Antibody / RNASEH1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids L7-Q223) was used as the immunogen for the Ribonuclease H1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Ribonuclease H1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Ribonuclease H1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Ribonuclease H1

Target: Ribonuclease H1 (RNASEH1)

Alternative Name: Ribonuclease H1

Background: Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17.

UniProt: O60930