LDLR antibody (AA 705-860)

Catalog No. ABIN7876593

The Rabbit Polyclonal anti-LDLR antibody is suitable to detect LDLR in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for LDLR antibody (AA 705-860) (ABIN7876593)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-LDLR Antibody

Binding Specificity: AA 705-860

Purpose: LDLR Antibody / LDL Receptor

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids A705-A860) was used as the immunogen for the LDLR antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LDLR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LDLR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR

Background: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low absorbance lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low absorbance lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism