OTC antibody (AA 71-98)

Catalog No. ABIN7876612

The Rabbit Polyclonal anti-OTC antibody (ABIN7876612) specifically detects OTC in WB, IHC (p) and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for OTC antibody (AA 71-98) (ABIN7876612)

Target: OTC (Ornithine Carbamoyltransferase (OTC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-OTC Antibody

Binding Specificity: AA 71-98

Purpose: Ornithine transcarbamylase Antibody / OTCase / OTC

Purification: Antigen affinity

Immunogen: A portion of amino acids 71-98 from the human protein was used as the immunogen for the Ornithine transcarbamylase antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Ornithine transcarbamylase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Ornithine transcarbamylase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for OTC

Target: OTC (Ornithine Carbamoyltransferase (OTC))

Alternative Name: Ornithine transcarbamylase

Background: Ornithine transcarbamylase is an enzyme that is responsible for catalyzing the reaction between ornithine and carbamoyl phosphate, ultimately forming citrulline. Citrulline then goes on to participate in the urea cycle, where it helps convert toxic ammonia into urea, which can be safely excreted by the body. A deficiency in this enzyme can lead to a rare genetic disorder known as ornithine transcarbamylase deficiency. Individuals with this condition are unable to properly metabolize ammonia, leading to a buildup of toxic levels in the blood. This can result in a range of symptoms, from mild to severe, including fatigue, seizures, and even coma if left untreated.

UniProt: P00480