CD207 antibody (AA 74-213)

Catalog No. ABIN7876709

This Mouse Monoclonal antibody specifically detects CD207 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for CD207 antibody (AA 74-213) (ABIN7876709)

Target: CD207 (CD207 Molecule, Langerin (CD207))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD207 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: LGRN-1821

Product Details anti-CD207 Antibody

Binding Specificity: AA 74-213

Purpose: Langerin Antibody / CD207

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 74-213) was used as the immunogen for the Langerin antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Langerin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Langerin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Alternative Name: Langerin

Background: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

UniProt: Q9UJ71