DNMT1 antibody (AA 767-912)

Catalog No. ABIN7876754

This Mouse Monoclonal antibody specifically detects DNMT1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for DNMT1 antibody (AA 767-912) (ABIN7876754)

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DNMT1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DNMT1-2061

Product Details anti-DNMT1 Antibody

Binding Specificity: AA 767-912

Purpose: DNMT1 Antibody

Purification: Protein G affinity chromatography

Immunogen: Amino acids 767-912 from the human protein was used as the immunogen for the DNMT1 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the DNMT1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the DNMT1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for DNMT1

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Alternative Name: DNMT1

Background: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE.

UniProt: P26358

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection