Fibrillarin antibody (AA 77-138)

Catalog No. ABIN7876758

The Rabbit Polyclonal anti-Fibrillarin antibody is suitable to detect Fibrillarin in samples from Human and Monkey. It has been validated for WB, IF, ELISA and FACS.

Quick Overview for Fibrillarin antibody (AA 77-138) (ABIN7876758)

Target: Fibrillarin (FBL)

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibrillarin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Product Details anti-Fibrillarin Antibody

Binding Specificity: AA 77-138

Purpose: FBL Antibody / Fibrillarin

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids K77-N138) was used as the immunogen for the FBL antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FBL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the FBL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Fibrillarin

Target: Fibrillarin (FBL)

Alternative Name: FBL

Background: RRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene. This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.

UniProt: P22087

Pathways: Ribonucleoside Biosynthetic Process