Ancient Ubiquitous Protein 1 antibody (AA 77-399)

Catalog No. ABIN7876763

This Rabbit Polyclonal antibody specifically detects Ancient Ubiquitous Protein 1 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for Ancient Ubiquitous Protein 1 antibody (AA 77-399) (ABIN7876763)

Target: Ancient Ubiquitous Protein 1 (Aup1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ancient Ubiquitous Protein 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Ancient Ubiquitous Protein 1 Antibody

Binding Specificity: AA 77-399

Purpose: Ancient ubiquitous protein 1 Antibody / AUP1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids A77-R399) was used as the immunogen for the Ancient ubiquitous protein 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Ancient ubiquitous protein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Ancient ubiquitous protein 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Ancient Ubiquitous Protein 1

Target: Ancient Ubiquitous Protein 1 (Aup1)

Alternative Name: Ancient ubiquitous protein 1

Background: Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene. The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants.

UniProt: Q9Y679