TRIM24 antibody (AA 789-843)

Catalog No. ABIN7876792

The Rabbit Polyclonal anti-TRIM24 antibody (ABIN7876792) specifically detects TRIM24 in WB, IF and IHC (p). The antibody is reactive with Mouse samples.

Quick Overview for TRIM24 antibody (AA 789-843) (ABIN7876792)

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM24 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TRIM24 Antibody

Binding Specificity: AA 789-843

Purpose: Trim24 Antibody / Tif1 alpha / Tif1a

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 789-843 from the mouse protein was used as the immunogen for the Trim24 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Trim24 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Trim24 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Alternative Name: Trim24

Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.

UniProt: Q64127