Ephrin A1 antibody (AA 83-115)

Catalog No. ABIN7876931

This Mouse Polyclonal antibody specifically detects Ephrin A1 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for Ephrin A1 antibody (AA 83-115) (ABIN7876931)

Target: Ephrin A1 (EFNA1)

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This Ephrin A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Ephrin A1 Antibody

Binding Specificity: AA 83-115

Purpose: EFNA1 Antibody / Ephrin A1

Immunogen: A portion of amino acids 83-115 from the human protein was used as the immunogen for the EFNA1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the EFNA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the EFNA1 antibody at -20oC.

Target Details for Ephrin A1

Target: Ephrin A1 (EFNA1)

Alternative Name: EFNA1

Background: Ephrin A1 is a membrane-bound protein that interacts with Eph receptors on neighboring cells, initiating a cascade of signals that regulate cell behavior and movement. This interaction is essential for processes such as cell migration, tissue organization, and synaptic connectivity in the nervous system. Studies have shown that dysregulation of Ephrin A1 signaling can lead to aberrant cell growth, invasion, and metastasis in cancer cells, highlighting its importance in disease progression. One of the key features of Ephrin A1 is its ability to both attract and repel cells, depending on the context and concentration of the molecule. This dual role allows Ephrin A1 to fine-tune cell-cell interactions and ensure proper tissue patterning during development. In the brain, for example, Ephrin A1 guides axonal growth and synapse formation, shaping the intricate neural circuits that underlie cognitive functions. In addition to its role in development, Ephrin A1 has also been implicated in several disease processes. Aberrant expression of EFNA1 has been observed in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth and invasion. In neurodegenerative disorders such as Alzheimer's disease, dysregulation of Ephrin A1 signaling disrupts synaptic connectivity and contributes to cognitive decline.

UniProt: P20827

Pathways: RTK Signaling