ELP2 antibody (AA 84-826)

Catalog No. ABIN7876963

The Rabbit Polyclonal anti-ELP2 antibody (ABIN7876963) specifically detects ELP2 in ELISA, WB, IF, FACS and ICC. The antibody is reactive with Human samples.

Quick Overview for ELP2 antibody (AA 84-826) (ABIN7876963)

Target: ELP2 (Elongator Acetyltransferase Complex Subunit 2 (ELP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELP2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Product Details anti-ELP2 Antibody

Binding Specificity: AA 84-826

Purpose: ELP2 Antibody / Elongator complex protein 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human ELP2 recombinant protein (Position: D84-L826) was used as the immunogen for the ELP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ELP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ELP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ELP2

Target: ELP2 (Elongator Acetyltransferase Complex Subunit 2 (ELP2))

Alternative Name: ELP2

Background: ELP2 antibody detects Elongator complex protein 2, encoded by the ELP2 gene. Elongator complex protein 2 is a subunit of the six-protein Elongator complex, which functions in transcriptional elongation, tRNA modification, and cytoskeletal regulation. ELP2 antibody provides researchers with a reagent for studying transcriptional control, RNA modification, and neuronal development.

The Elongator complex associates with RNA polymerase II and facilitates transcriptional elongation by modifying chromatin and RNA. Research using ELP2 antibody has shown that Elongator promotes efficient transcription of genes involved in development and stress responses. It also plays an important role in acetylation of histones, linking transcription to chromatin structure.

Studies with ELP2 antibody have revealed that Elongator regulates wobble base modifications in tRNA, ensuring accurate translation and proteome stability. Loss of ELP2 disrupts codon decoding and protein synthesis, impairing cellular growth and differentiation. These functions underscore its significance beyond transcriptional control.

Dysregulation of Elongator complex protein 2 has been associated with neurodevelopmental and neurological disorders. Research using ELP2 antibody has shown that variants in Elongator subunits contribute to familial dysautonomia and intellectual disability syndromes. In neuronal systems, ELP2 influences migration, axonal outgrowth, and synaptic development, highlighting its role in brain function.

Beyond neurology, Elongator impacts immune responses and tumor biology. Research using ELP2 antibody has indicated that altered expression affects stress-induced gene expression, cell migration, and invasion in cancer. These findings expand its biological scope.

ELP2 antibody is widely applied in western blotting, immunohistochemistry, and RNA-protein interaction studies. Western blotting quantifies protein levels in tissues, immunohistochemistry demonstrates localization, and interaction studies identify Elongator-associated RNAs and proteins. These applications make ELP2 antibody indispensable for research in transcriptional and translational regulation.

By providing validated ELP2 antibody reagents, NSJ Bioreagents supports studies into transcriptional elongation, tRNA modification, and neurodevelopment. Detection of Elongator complex protein 2 provides researchers with insight into how transcriptional cofactors regulate gene expression and disease.

UniProt: Q6IA86

Pathways: Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus