VWF antibody (AA 845-949)

Catalog No. ABIN7876966

The Mouse Monoclonal anti-VWF antibody (Clone VWF-4105) (ABIN7876966) specifically detects VWF in IHC (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for VWF antibody (AA 845-949) (ABIN7876966)

Target: VWF (Von Willebrand Factor (VWF))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This VWF antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: VWF-4105

Product Details anti-VWF Antibody

Binding Specificity: AA 845-949

Purpose: von Willebrand Factor Antibody

Purification: Protein A/G affinity

Immunogen: A recombinant human vWF fragment protein sequence (within amino acids 845-949) was used as the immunogen for the von Willebrand Factor antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the von Willebrand Factor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the von Willebrand Factor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for VWF

Target: VWF (Von Willebrand Factor (VWF))

Alternative Name: von Willebrand Factor

Background: Von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.

UniProt: P04275