SMAD7 antibody (AA 88-135)

Catalog No. ABIN7877026

The Rabbit Polyclonal anti-SMAD7 antibody (ABIN7877026) specifically detects SMAD7 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SMAD7 antibody (AA 88-135) (ABIN7877026)

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SMAD7 Antibody

Binding Specificity: AA 88-135

Purpose: MADH7 Antibody / SMAD7

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids A88-R135) was used as the immunogen for the MADH7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MADH7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MADH7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SMAD7

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Alternative Name: MADH7

Background: Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization