NAV3 antibody (AA 9-1417)

Catalog No. ABIN7877064

The Rabbit Polyclonal anti-NAV3 antibody is suitable to detect NAV3 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for NAV3 antibody (AA 9-1417) (ABIN7877064)

Target: NAV3 (Neuron Navigator 3 (NAV3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAV3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NAV3 Antibody

Binding Specificity: AA 9-1417

Purpose: NAV3 Antibody / Neuron navigator 3

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human NAV3 recombinant protein (Position: K9-D1417) was used as the immunogen for the NAV3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NAV3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NAV3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NAV3

Target: NAV3 (Neuron Navigator 3 (NAV3))

Alternative Name: NAV3

Background: NAV3 antibody detects Neuron navigator 3, a cytoskeletal-associated protein that regulates axon guidance, neuronal migration, and cytoskeletal organization. Encoded by the NAV3 gene on chromosome 12q21.2, this protein belongs to the neuron navigator family, which also includes NAV1 and NAV2, and is characterized by coiled-coil and calponin homology domains that facilitate interaction with microtubules and actin filaments. NAV3 plays a pivotal role in neuronal development and guidance by stabilizing the cytoskeleton and modulating microtubule dynamics during axon extension.

NAV3 localizes primarily to neuronal growth cones and extending axons, where it influences the assembly and organization of cytoskeletal networks required for directional growth. It interacts with signaling molecules involved in cytoskeletal regulation, including Rho GTPases and kinases that modulate actin-microtubule coordination. Beyond its developmental roles, NAV3 contributes to cytoskeletal remodeling in mature neurons and glial cells, supporting plasticity and response to injury.

The NAV3 antibody is used in neuroscience and developmental biology research to study axon formation, neuronal polarity, and migration. Western blot analysis identifies a 250 kilodalton band corresponding to NAV3, while immunofluorescence reveals punctate and filamentous staining along axons and dendritic processes. This antibody enables detailed visualization of cytoskeletal organization and neuronal network formation.

Altered NAV3 expression is associated with neurodevelopmental disorders, epilepsy, and gliomas, where disrupted cytoskeletal control affects cell morphology and migration. Additionally, NAV3 has been linked to wound healing and skin differentiation, as its expression is upregulated during keratinocyte migration. The NAV3 antibody provides a robust tool for analyzing cytoskeletal guidance mechanisms and neuronal development. NSJ Bioreagents offers this antibody validated for its applications, ensuring reproducible performance in studies of neuronal and cytoskeletal regulation.

UniProt: Q8IVL0