Bestrophin 1 antibody (AA 9-551)

Catalog No. ABIN7877093

This Rabbit Polyclonal antibody specifically detects Bestrophin 1 in WB and ELISA. It exhibits reactivity toward Mouse and Rat.

Quick Overview for Bestrophin 1 antibody (AA 9-551) (ABIN7877093)

Target: Bestrophin 1 (BEST1)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bestrophin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Bestrophin 1 Antibody

Binding Specificity: AA 9-551

Purpose: Best1 Antibody / Bestrophin 1

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived mouse recombinant protein (amino acids V9-E551) was used as the immunogen for the Best1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Best1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Best1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Bestrophin 1

Target: Bestrophin 1 (BEST1)

Alternative Name: Best1

Background: Bestrophin-1 (Best1) is a protein that in humans is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

UniProt: O88870