Plakophilin 2 antibody (AA 9-866)

Catalog No. ABIN7877099

This Rabbit Polyclonal antibody specifically detects Plakophilin 2 in WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Plakophilin 2 antibody (AA 9-866) (ABIN7877099)

Target: Plakophilin 2 (PKP2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Plakophilin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Plakophilin 2 Antibody

Binding Specificity: AA 9-866

Purpose: PKP2 Antibody / Plakophilin 2

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant mouse protein (amino acids E9-D866) was used as the immunogen for the PKP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PKP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PKP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Plakophilin 2

Target: Plakophilin 2 (PKP2)

Alternative Name: PKP2

Background: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13.

UniProt: Q99959

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection