Recombinant TARDBP antibody (C-Term)

Catalog No. ABIN7877485

The Rabbit Monoclonal anti-TARDBP antibody (Clone TARDP-9299R) (ABIN7877485) specifically detects TARDBP in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant TARDBP antibody (C-Term) (ABIN7877485)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TARDP-9299R

Product Details anti-TARDBP Antibody

Binding Specificity: C-Term

Purpose: Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant fragment within human TDP43 aa 200 to the C-terminus was used as the immunogen for the recombinant TDP43 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant TDP43 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant TDP43 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TDP43

Background: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion