Recombinant Ki-67 antibody (full length)

Catalog No. ABIN7877688

The Mouse Monoclonal anti-Ki-67 antibody is suitable to detect Ki-67 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Ki-67 antibody (full length) (ABIN7877688)

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ki-67 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RMKI67-8852

Product Details anti-Ki-67 Antibody

Binding Specificity: full length

Purpose: Ki-67 Antibody

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human MKI67 protein was used as the immunogen for the Ki-67 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Ki-67 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Ki-67 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Ki-67

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Alternative Name: Ki-67

Background: Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.

UniProt: P46013

Pathways: Glycosaminoglycan Metabolic Process