Recombinant beta-2 Microglobulin antibody (full length)

Catalog No. ABIN7877720

This Rabbit Monoclonal antibody specifically detects beta-2 Microglobulin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant beta-2 Microglobulin antibody (full length) (ABIN7877720)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: B2M-7013R

Product Details anti-beta-2 Microglobulin Antibody

Binding Specificity: full length

Purpose: Recombinant B2M Antibody / Beta-2 Microglobulin (azide and preservative free)

Purification: Protein A affinity

Immunogen: Recombinant full-length human B2M protein was used as the immunogen for the recombinant B2M antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant B2M antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant B2M antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: B2M

Background: Recognizes a protein of 12 kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process