Recombinant beta-2 Microglobulin antibody (full length)

Catalog No. ABIN7877723

This Mouse Monoclonal antibody specifically detects beta-2 Microglobulin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant beta-2 Microglobulin antibody (full length) (ABIN7877723)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2M-7279

Product Details anti-beta-2 Microglobulin Antibody

Binding Specificity: full length

Purpose: Recombinant Beta-2 Microglobulin Antibody

Purification: Protein A affinity

Immunogen: Recombinant full-length human B2M protein was used as the immunogen for the recombinant Beta-2 Microglobulin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Beta-2 Microglobulin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Beta-2 Microglobulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: Beta-2 Microglobulin

Background: Recognizes a protein of 12 kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process