Recombinant N-Cadherin antibody (full length)

Catalog No. ABIN7877738

This Rabbit Monoclonal antibody specifically detects N-Cadherin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant N-Cadherin antibody (full length) (ABIN7877738)

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This N-Cadherin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CDH2-7070R

Product Details anti-N-Cadherin Antibody

Binding Specificity: full length

Purpose: Recombinant Cadherin 2 Antibody / CDH2 / N-Cadherin

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the recombinant Cadherin 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant Cadherin 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Cadherin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for N-Cadherin

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Alternative Name: Cadherin 2

Background: Recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325, Cadherin 2 and CDH2. CDH2 is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CDH2 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, the protein has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CDH2 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane