Recombinant Caldesmon antibody (full length)

Catalog No. ABIN7877756

This Mouse Monoclonal antibody specifically detects Caldesmon in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant Caldesmon antibody (full length) (ABIN7877756)

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Caldesmon antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RCALD1-7266

Product Details anti-Caldesmon Antibody

Binding Specificity: full length

Purpose: Recombinant CALD1 Antibody/ Caldesmon / CAD (HMW)

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length CALD1 protein was used as the immunogen for the recombinant CALD1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant CALD1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant CALD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Caldesmon

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Alternative Name: CALD1

Background: Recognizes a protein of 150 kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120-150 kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70-80 kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This MAb recognizes only the 150 kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.

UniProt: Q05682

Pathways: Myometrial Relaxation and Contraction