Calpain antibody (full length)

Catalog No. ABIN7877759

This Mouse Monoclonal antibody specifically detects Calpain in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Calpain antibody (full length) (ABIN7877759)

Target: Calpain

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Calpain antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CAPN1-1530

Product Details anti-Calpain Antibody

Binding Specificity: full length

Purpose: Calpain Antibody / CAPN1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human CAPN1 protein was used as the immunogen for this Calpain antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Calpain antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Calpain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Calpain

Target: Calpain

Background: Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

UniProt: P07384