Recombinant CA8 antibody (full length)

Catalog No. ABIN7877777

This Mouse Monoclonal antibody specifically detects CA8 in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant CA8 antibody (full length) (ABIN7877777)

Target: CA8 (Carbonic Anhydrase VIII (CA8))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CA8 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RCA8-8835

Product Details anti-CA8 Antibody

Binding Specificity: full length

Purpose: CA8 Antibody / Carbonic Anhydrase VIII

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the CA8 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CA8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CA8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CA8

Target: CA8 (Carbonic Anhydrase VIII (CA8))

Alternative Name: CA8

Background: The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

UniProt: P35219